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Taking Clomid For Infertility

Clomid, also known as clomiphene citrate, is a medication commonly prescribed to treat infertility in women. In this guide, we’ll explore the workings of Clomid, its various applications, dosage, potential side effects, and more.

How Clomid Works

Mechanism of Action

It works by stimulating the release of hormones necessary for ovulation. It acts as a selective oestrogen receptor modulator (SERM), blocking oestrogen receptors in the hypothalamus. This, in turn, triggers the release of follicle-stimulating hormone (FSH) and luteinising hormone (LH), essential for the growth and release of mature eggs from the ovaries.


Primarily, it is prescribed to women who have difficulty ovulating, whether due to polycystic ovary syndrome (PCOS), irregular menstrual cycles, or unexplained infertility.

Dosage and Administration

Typical Dosage

The typical starting dose is 50 milligrams (mg) per day, usually taken for five days, beginning on the fifth day of the menstrual cycle.

Administration Guidelines

It’s important to follow your healthcare professional’s instructions precisely. It is usually taken orally, with or without food, at the same time each day.

Potential Side Effects

Common Side Effects

Some women may experience hot flashes, mood swings, breast tenderness, nausea, or headaches while taking Clomid. These side effects are usually mild and temporary.

Rare but Serious Side Effects

In rare cases, it may cause more severe side effects such as visual disturbances, abdominal pain, and ovarian hyperstimulation syndrome (OHSS). If you experience any unusual symptoms, contact your doctor immediately.

Safety Considerations


Before taking Clomid, inform your doctor of any existing medical conditions or medications you’re currently taking. It may not be suitable for women with certain hormone-related conditions or liver disease.


It is contraindicated in pregnant women, women with abnormal uterine bleeding, and those with ovarian cysts or enlarged ovaries not due to polycystic ovary syndrome.

Clomid for Fertility Treatment

Usage in Women

It is often the first-line treatment for ovulatory dysfunction in women trying to conceive. It can help regulate ovulation and improve the chances of pregnancy.

Usage in Men

In men, it may be prescribed off-label to treat infertility caused by low testosterone levels. It can stimulate the production of testosterone and improve sperm count and motility.

Clomid and Ovulation Induction

It is commonly used in assisted reproductive technology (ART) procedures to induce ovulation, particularly in women undergoing intrauterine insemination (IUI) or in vitro fertilisation (IVF) cycles.

Clomid and Polycystic Ovary Syndrome (PCOS)

For women with PCOS, it can help induce regular ovulation and increase the chances of conception. It’s often used as a first-line treatment in these cases.

Clomid and Breast Cancer

There’s ongoing research into the potential link between Clomid use and an increased risk of breast cancer. While some studies suggest a slight increase in risk, more research is needed to establish a definitive connection.

Clomid and Twins

Clomid use may slightly increase the likelihood of conceiving twins or multiple pregnancies due to the stimulation of multiple eggs. However, the risk of multiple pregnancies is still relatively low.

Alternatives to Clomid

For individuals who cannot tolerate it or do not respond to treatment, alternative medications or assisted reproductive techniques may be considered. These include injectable fertility drugs, ovarian drilling surgery, or IVF with or without donor eggs or sperm.

Clomid is a widely used medication for treating infertility in both men and women. Its ability to induce ovulation has helped countless couples achieve their dream of parenthood. However, like any medication, it’s important to use it under the guidance of a healthcare professional and be aware of potential side effects and safety considerations.


Is Clomid safe for long-term use?

While it is generally considered safe for short-term use, prolonged use may increase the risk of certain side effects. It’s important to discuss any concerns with your doctor.

Can Clomid increase the chances of multiple pregnancies?

Yes, it can increase the likelihood of conceiving twins or multiples due to the stimulation of multiple eggs. However, the risk is still relatively low compared to other fertility treatments.

How long does it typically take to conceive on Clomid?

The success rate of Clomid varies from person to person. Some women may conceive within the first few cycles, while others may require several months of treatment.

Are there any lifestyle changes that can improve Clomid’s effectiveness?

Maintaining a healthy lifestyle, including a balanced diet, regular exercise, and avoiding tobacco and excessive alcohol consumption, can help optimise fertility outcomes when taking Clomid.

Can Clomid be purchased over the counter?

No, Clomid is a prescription medication and should only be taken under the supervision of a qualified healthcare professional.

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